Endocannabinoid System and CBD


The discovery of the endocannabinoid system (ECS) was in the early to mid 1990s. Recent science has found that the system not only response to the endocannabinoids produced in the body, but also to external cannabinoids like the phytocannabinoid cannabidiol, or CBD.

Two of the main receptors within this system are cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2). Neurons act as a lock and the cannabinoids are a key. 

Cannabinoid Receptor Type 1 (CB1)

Discovered in 1990 and has high numbers within the hypothalamus, hippocampus, amygdala, central nervous system,  intestines, connective tissues, and gonads. 

Benefits of activating CB1:

Relieving depression
Increasing myelin formation
Lowering intestinal inflammation
Decreasing Leaky Gut Syndrome
Lowering blood pressure
Lowering anxiety 
Reducing fear and paranoia 
Increasing BDNF levels 
Increasing PPARy expression 
Reducing GPR55 signaling 
Lowering prolactin 

Cannabinoid Receptor Type 2 (CB2)

Discovered in 1993 found in the spleen, tonsils, thymus, monocytes, macrophages, B and T cells, and microglia. Changes to CB2 can help with almost any type of illness: cardiovascular, gastrointestinal, neurodegenerative, psychiatric, and autoimmune. Activation also induces macrophages to destroy the beta-amyloid protein plaque found in the brains of people with Alzheimer’s disease. 

Endogenous Cannabinoids

Endogenous Cannabinoids are neurotransmitters produced within the body. These bind to the cannabinoid receptors. These are the anandamide, 2-arachidonoylglycerol (2-AG), n-arachidonoyl dopamine (NADA), and virodhamine (OAE). They can not travel very far in the body so there effects are localized. 

CBD 

Unlike THC, CBD has a binding ability so affects the CB1 and CB2 in an indirect way. One way is to activate the TRPV1 receptor. This receptor helps in regulating pain, body temperature, and inflammation. CBD also inhibit Fatty Acid Amide Hydrolase (FAAH). This will create a higher level of endocannabinoids.

According to the National Institute of Health, introducing external cannabinoids like CBD could be a help in treating medical illnesses like:

Pain
Epilepsy
Multiple Sclerosis (MS)
Amyotrophic Lateral Sclerosis (ALS)
Parkinson’s
Inflammation
Acne
Dyskinesia
Psoriasis
Broken Bones
Mad Cow Disease
Depression
Bacterial Infections
Diabetes
Rheumatoid Arthritis
Nausea
Anxiety
ADHD
Schizophrenia
Substance Abuse/Withdrawal
Heart Disease
Irritable Bowel Syndrome (IBS)

New studies are happening all the time and this list is expected to grow. 
https://www.tryctfo.com/awakenedvegan/index.html


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